Pyrolite-TB Tablets

INR 89.00 / Pack
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Business Type Exporter, Supplier, Trader
Form Tablets
Pack Type Blister
Strength 250 mg
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Location Worldwide

Product Details

Dosage
As Prescribed by Physician
Manufacturer
Apsolabs

Salt Composition

  • N acetylcysteine 250 Mg
  • Pyridoxin Hydrochloride: -50 Mg
  • Ascorbic Acid (Vitamin C): - 75 Mg
  • Vitamin E: - 200 IU
  • Vitamin A: - 900 IU
  • Zinc: - 8 Mg
  • Folic Acid; - 5 Mg

 

Introduction: Tuberculosis Challenges: Ahead

  • As per the Global TB report 2017 the estimated incidence of TB in India was approximately 28,00,000 accounting for about a quarter of the world’s TB cases.
  • India continues to have the highest number of tuberculosis (TB) cases in the world
  • Tuberculosis is probably associated with more severe malnutrition than other chronic illnesses
  • A less than ideal weight gain during TB treatment also increases the risk of long-term relapse even after initial cure. Under nutrition has also been associated with malabsorption of key anti TB drugs.
  • Majority of TB patients notified are from the age group of 15-45 years and they are from the lower socio-economic strata of the society.
  • Also, since they are from working group age, TB disease affects the income of the family also while patients are on care.
  • There is increasing evidence that under nutrition in patients with active TB is associated with an increased frequency and severity of disease and indeed a two-to-four-fold increase in mortality. There is also a fivefold risk of drug induced liver damage.
  • Peripheral neuropathy is a well-known adverse effect of Isoniazid.
  • Anti-tuberculosis drug-induced liver injury (TB DILI) is a leading cause of DILI and drug-induced acute liver failure (DIALF) in India and much of the developing world.
  • Marked oxidative stresses were seen in the TB population as compared to the healthy cohort.
  • 20% of patients develop asymptomatic elevation of liver enzymes which is self-limiting (as a result of adaptation or discontinuance) in a majority of patients (1)
  • Anorexia is also a contributing factor for wasting in tuberculosis.
  • Malnourished tuberculosis patients have delayed recovery and higher mortality rates than well-nourished patients. (8)
  • TB and under nutrition can cause a vicious cycle of worsening disease and under nutrition.
  • Disease: Increased severity & higher mortality
  • Treatment: Increased adverse effects (liver toxicity), malabsorption of drugs such as rifampicin, increased relapse after cure, delayed sputum conversion
  • TB transmission in household: Increased risk of TB incidence in undernourished contacts.

 

TB Nutritional Care & Support

In more developed countries, only a few people with TB will need nutritional care & support as part of their TB treatment and care. In other countries, such as India, the majority of people with TB may need nutritional care & support. There are a number of principles for providing nutritional care and support as a necessary part of TB care and prevention and these include.

  • When under nutrition is identified at the time of TB diagnosis, TB must be considered a key cause that needs to be addressed.
  • An adequate diet is necessary for the well-being and health of all people, including those with TB infection or TB disease.
  • Because of the clear two-way link between under nutrition and active TB, nutritional assessment and counselling are vital parts of TB treatment and care.
  • Poverty and food insecurity are both causes and consequences of TB, and those involved in TB care therefore play an important role in recognizing and addressing these wider socioeconomic issues.
  • TB is commonly accompanied by co-morbidities such as HIV, diabetes, smoking and alcohol or substance abuse, which has their own nutritional implications and these, should be fully considered during nutrition assessment and counselling.

 

N-Acetylcysteine (NAC) 250 Mg: -

  • Protective effects seen in Anti-TB drug induced hepatotoxicity.
  • The Antioxidant role of glutathione supplements seen in reducing oxidative stress
  • Nac is strong mucolytic and helps in expectoration

 

Pyridoxin HCL:-

  • Prevent the development of peripheral neuropathy caused by Isoniazid  

 

Ascorbic Acid: -

  • Washington, DC – January 3, 2018 – Studies in mice and in tissue cultures suggest that giving vitamin C with tuberculosis drugs could reduce the unusually long time it takes these drugs to eradicate this pathogen.

 

Vitamin E: -

  • Currently, micronutrient deficiencies are thought to be the most common cause of secondary   immunodeficiency and the most prominent risk factor for infection-related morbidity, which potentially affect individuals’ susceptibility to tuberculosis and may alter the natural course of this disease (4).

 

Zinc & Vitamin A

  • "The effectiveness of anti-tuberculosis treatment was improved during the first two months by vitamin A and zinc supplementation," Dr. Clive E. West, a professor in the department of nutrition at Wageningen University in the Netherlands, and colleagues write in the April issue of the American Journal of Clinical Nutrition (2002;75:720-727).

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